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Evaluation of clinically relevant sevoflurane concentrations in the development of malignant hyperthermia in an Ryr1 mutant mouse model.

BMC anesthesiology - 24 Mar 2026

Kido Kenshiro, Miyoshi Hirotsugu, Ikeda Tsuyoshi, Xia Guoqiang, Sumii Ayako, Otsuki Sachiko, Mukaida Keiko, Sotomaru Yusuke, Noguchi Satoru, Tsutsumi Yasuo M

Abstract excerpt

BACKGROUND: Malignant hyperthermia (MH) is associated with mutations in the RYR1 gene; however, the effect of volatile anesthetic concentrations on the clinical symptoms of patients with MH is unknown. We investigated the effects of high concentrations of volatile anesthetics on MH development and progression. METHODS: MH mouse models with R2509C mutation in Ryr1, all male, approximately 15 weeks old were...

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Anesthetics, Inhalation
Body Temperature
Disease Models, Animal
Dose-Response Relationship, Drug
Heart Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Malignant Hyperthermia

Ryanodine Receptor Calcium Release Channel

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Open in PubMed Open full text

Identifiers

PMID: 41877010
DOI: 10.1186/s12871-026-03779-y
PMCID: PMC13134110

Genes

RYR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Evaluation of clinically relevant sevoflurane concentrations in the development of malignant hyperthermia in an Ryr1 mutant mouse model.PMID 41877010Read ↗

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