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Mutational analysis of human papillomavirus type 16 major capsid protein L1: the cysteines affecting the intermolecular bonding and structure of L1-capsids.

Virology - 30 Mar 2003

Ishii Yoshiyuki, Tanaka Keiko, Kanda Tadahito

Abstract excerpt

Human papillomavirus 16 major capsid protein L1 (composed of 505 amino acids (aa) including 12 cysteines) assembles by itself into virion-like icosahedral particles (L1-capsids), each of which is dissociated into 72 pentameric capsomeres when intermolecular disulfide bonds are disrupted. To identify the cysteines affecting the bonding and the structural integrity of the L1-capsids, we constructed a series of L1...

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PMID: 12706096
DOI: 10.1016/s0042-6822(02)00099-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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