Article
Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles.
Journal of virology - 1 Dec 1993
Kirnbauer R, Taub J, Greenstone H, Roden R, Dürst M, Gissmann L, Lowy D R, Schiller J T
Abstract excerpt
The L1 genes of two human papillomavirus type 16 (HPV16) isolates derived from condylomata acuminata were used to express the L1 major capsid protein in insect cells via recombinant baculoviruses. Both L1 major capsid proteins self-assembled into virus-like particles (VLP) with high efficiency an...
Topics
- Animals
- Baculoviridae
- Base Sequence
- Capsid
- Capsid Proteins
- Cells, Cultured
- Condylomata Acuminata
- Genes, Viral
- Humans
- Molecular Sequence Data
- Morphogenesis
- Moths
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae
- Precipitin Tests
- Recombinant Proteins
- Sequence Analysis