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Article

Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles.

Journal of virology - 1 Dec 1993

Kirnbauer R, Taub J, Greenstone H, Roden R, Dürst M, Gissmann L, Lowy D R, Schiller J T

Abstract excerpt

The L1 genes of two human papillomavirus type 16 (HPV16) isolates derived from condylomata acuminata were used to express the L1 major capsid protein in insect cells via recombinant baculoviruses. Both L1 major capsid proteins self-assembled into virus-like particles (VLP) with high efficiency and could be purified in preparative amounts on density gradients. The yield of VLP was 3 orders of magnitude higher than...

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Identifiers

PMID: 8230414
DOI: 10.1128/JVI.67.12.6929-6936.1993
PMCID: PMC238150

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