Article
Critical Residues Involved in the Coassembly of L1 and L2 Capsid Proteins of Human Papillomavirus 16.
Journal of virology - 30 Mar 2023
Chen Jie, Wang Daning, Wang Zhiping, Wu Kunbao, Wei Shuangping, Chi Xin, Qian Ciying, Xu Yujie, Zhou Lizhi, Li Yuqian, Zhang Sibo, Li Tingting, Kong Zhibo, Wang Yingbin, Zheng Qingbing, Yu Hai, Zhao Qinjian, Zhang Jun, Xia Ningshao, Li Shaowei, Gu Ying
Abstract excerpt
Human papillomaviruses (HPV) are small DNA viruses associated with cervical cancer, warts, and other epithelial tumors. Structural studies have shown that the HPV capsid consists of 360 copies of the major capsid protein, L1, arranged as 72 pentamers in a T=7 icosahedral lattice, coassembling with substoichiometric amounts of the minor capsid protein, L2. However, the residues involved in the coassembly of L1 and...
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