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Article

Mutant canine oral papillomavirus L1 capsid proteins which form virus-like particles but lack native conformational epitopes.

The Journal of general virology - 1 Sept 1998

Chen Y, Ghim S J, Jenson A B, Schlegel R

Abstract excerpt

Recently, the L1 capsid protein of canine oral papillomavirus (COPV) has been used as an effective systemic vaccine that prevents viral infections of the oral mucosa. The efficacy of this vaccine is critically dependent upon native L1 conformation and, when purified from Sf9 insect cells, the L1 protein not only displays type-specific, conformation-dependent epitopes but it also assembles spontaneously into...

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PMID: 9747722
DOI: 10.1099/0022-1317-79-9-2137

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