Article
Mutant canine oral papillomavirus L1 capsid proteins which form virus-like particles but lack native conformational epitopes.
The Journal of general virology - 1 Sept 1998
Chen Y, Ghim S J, Jenson A B, Schlegel R
Abstract excerpt
Recently, the L1 capsid protein of canine oral papillomavirus (COPV) has been used as an effective systemic vaccine that prevents viral infections of the oral mucosa. The efficacy of this vaccine is critically dependent upon native L1 conformation and, when purified from Sf9 insect cells, the L1...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Viral
- Base Sequence
- Capsid
- Capsid Proteins
- DNA Primers
- Dogs
- Epitopes
- Humans
- Microscopy, Electron
- Microscopy, Fluorescence
- Molecular Sequence Data
- Mutation
- Papillomaviridae
- Polymerase Chain Reaction
- Protein Conformation
- Protein Folding