Article
Structure-based engineering of papillomavirus major capsid l1: controlling particle assembly.
Virology journal - 8 Jan 2007
Bishop Brooke, Dasgupta Jhimli, Chen Xiaojiang S
Abstract excerpt
The outer shell of the papillomavirus particle is comprised of 72 pentamers of the major capsid L1 protein arranged on a T = 7 icosahedral lattice. The recombinant L1 can form T = 7 virus-like particles in vitro. The crystal structure of a T = 7 papilloma virion has not yet been determined; however, the crystal structure of a T = 1 particle containing 12 pentamers is known. The T = 1 structure reveals that...
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