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Article

Papillomavirus assembly requires trimerization of the major capsid protein by disulfides between two highly conserved cysteines.

Journal of virology - 1 Jul 1998

Sapp M, Fligge C, Petzak I, Harris J R, Streeck R E

Abstract excerpt

We have used viruslike particles (VLPs) of human papillomaviruses to study the structure and assembly of the viral capsid. We demonstrate that mutation of either of two highly conserved cysteines of the major capsid protein L1 to serine completely prevents the assembly of VLPs but not of capsomer...

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Identifiers

PMID: 9621087
DOI: 10.1128/JVI.72.7.6186-6189.1998
PMCID: PMC110432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9621087-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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