Article
Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat.
Biochemical and biophysical research communications - 25 Apr 2003
Masuyama Taku, Fuse Masanori, Yokoi Norihide, Shinohara Masami, Tsujii Hirotada, Kanazawa Masao, Kanazawa Yasunori, Komeda Kajuro, Taniguchi Kazuyuki
Abstract excerpt
The Spontaneously Diabetic Torii (SDT) rat has recently been established as a new rat model of nonobese type 2 diabetes. In this study, we characterized diabetic features in SDT rats, and performed quantitative trait locus (QTL) analysis for glucose intolerance using 319 male (BNxSDT)xSDT backcrosses. Male SDT rats exhibited glucose intolerance at 20 weeks, and spontaneously developed diabetes with the incidence...
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