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Article

Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease.

Science (New York, N.Y.) - 16 May 2003

Foy Eileen, Li Kui, Wang Chunfu, Sumpter Rhea, Ikeda Masanori, Lemon Stanley M, Gale Michael

Abstract excerpt

Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We show that the HCV NS3/4A serine protease blocks the phosphorylation and effector action of interferon regulatory factor-3 (IRF-3), a key cellular antiviral signaling molecule. Disruption of NS3/4A protease function by mutation or a ketoamide peptidomimetic inhibitor relieved this blockade and restored...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12702807
DOI: 10.1126/science.1082604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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