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Article

In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor.

Journal of virology - 1 Mar 2003

Trozzi Caterina, Bartholomew Linda, Ceccacci Alessandra, Biasiol Gabriella, Pacini Laura, Altamura Sergio, Narjes Frank, Muraglia Ester, Paonessa Giacomo, Koch Uwe, De Francesco Raffaele, Steinkuhler Christian, Migliaccio Giovanni

Abstract excerpt

The hepatitis C virus (HCV) serine protease is necessary for viral replication and represents a valid target for developing new therapies for HCV infection. Potent and selective inhibitors of this enzyme have been identified and shown to inhibit HCV replication in tissue culture. The optimization of these inhibitors for clinical development would greatly benefit from in vitro systems for the identification and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

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Source

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Identifiers

PMID: 12610142
DOI: 10.1128/jvi.77.6.3669-3679.2003
PMCID: PMC149541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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