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Article

Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors.

Biochemistry - 8 Dec 2009

Dahl Göran, Arenas Omar Gutiérrez, Danielson U Helena

Abstract excerpt

The nonstructural protein 3 (NS3) of hepatitis C virus (HCV) is a bifunctional enzyme with a protease and a helicase functionality located in each of the two domains of the single peptide chain. There is little experimental evidence for a functional role of this unexpected arrangement since artificial single domain forms of both enzymes are catalytically competent. We have observed that low concentrations of...

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Identifiers

PMID: 19839643
DOI: 10.1021/bi9016928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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