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Article

Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation

24 Feb 2014

Abstract excerpt

The use of pegylated interferon-α (pegIFN-α) has replaced unmodified recombinant IFN-α for the treatment of chronic viral hepatitis. While the superior antiviral efficacy of pegIFN-α is generally attributed to improved pharmacokinetic properties, the pharmacodynamic effects of pegIFN-α in the liver have not been studied. Here, we analyzed pegIFN-α-induced signaling and gene regulation in paired liver biopsies...

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PMID: 24569457
DOI: 10.1172/jci70408

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