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Article

ASPP2 suppresses squamous cell carcinoma via RelA/p65–mediated repression of p63

14 Oct 2013

Abstract excerpt

Squamous cell carcinoma (SCC) is highly malignant and refractory to therapy. The majority of existing mouse SCC models involve multiple gene mutations. Very few mouse models of spontaneous SCC have been generated by a single gene deletion. Here we report a haploinsufficient SCC mouse model in which exon 3 of the Tp53BP2 gene (a p53 binding protein) was deleted in one allele in a BALB/c genetic background. Tp53BP2...

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PMID: 24127607
DOI: 10.1073/pnas.1309362110

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