Predictive and prognostic role of p53 according to tumor phenotype in breast cancer patients treated with preoperative chemotherapy: a single-institution analysis.

doi:10.1177/172460081002500208

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Article

Predictive and prognostic role of p53 according to tumor phenotype in breast cancer patients treated with preoperative chemotherapy: a single-institution analysis.

The International journal of biological markers - 1 Jan 2000

Guarneri Valentina, Barbieri Elena, Piacentini Federico, Giovannelli Simona, Ficarra Guido, Frassoldati Antonio, Maiorana Antonino, D'Amico Roberto, Conte Pierfranco

Abstract excerpt

INTRODUCTION AND AIMS: The p53 protein is a mediator of the cellular response to DNA damage. The aim of this study was to evaluate the predictive and/or prognostic value of p53 expression in relation to the molecular subtypes of breast cancer in patients treated with preoperative chemotherapy. PATIENTS AND METHODS: Patients with stage II-III breast cancer were included in the study. The expression of p53 was...

Topics

Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Breast Neoplasms
Carcinoma, Ductal, Breast
Chemotherapy, Adjuvant
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mastectomy, Segmental

Middle Aged

Phenotype

Predictive Value of Tests

Preoperative Period

Prognosis

Remission Induction

Survival Analysis

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 20544688
DOI: 10.1177/172460081002500208

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