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The Cell-Cycle State of Stem Cells Determines Cell Fate Propensity

1 Sept 2013

Abstract excerpt

Self-renewal and differentiation of stem cells are fundamentally associated with cell-cycle progression to enable tissue specification, organ homeostasis, and potentially tumorigenesis. However, technical challenges have impaired the study of the molecular interactions coordinating cell fate choice and cell-cycle progression. Here, we bypass these limitations by using the FUCCI reporter system in human...

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PMID: 24074866
DOI: 10.1016/j.cell.2013.08.031

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