Article
Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling.
Developmental biology - 15 Oct 2002
Kramer Carina, Mayr Thomas, Nowak Matthias, Schumacher Jennifer, Runke Greg, Bauer Hermann, Wagner Daniel S, Schmid Bettina, Imai Yoshiyuki, Talbot William S, Mullins Mary C, Hammerschmidt Matthias
Abstract excerpt
We have previously shown that the maternal effect dorsalization of zebrafish embryos from sbn(dtc24) heterozygous mothers is caused by a dominant negative mutation in Smad5, a transducer of ventralizing signaling by the bone morphogenetic proteins Bmp2b and Bmp7. Since sbn(dtc24) mutant Smad5 protein not only blocks wild-type Smad5, but also other family members like Smad1, it remained open to what extent Smad5...
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