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Article

Low microsatellite instability: A distinct instability type in gastric cancer?

Journal of cancer research and clinical oncology - 1 Dec 2023

Kohlruss Meike, Chakraborty Shounak, Hapfelmeier Alexander, Jesinghaus Moritz, Slotta-Huspenina Julia, Novotny Alexander, Sisic Leila, Gaida Matthias M, Ott Katja, Weichert Wilko, Pfarr Nicole, Keller Gisela

Abstract excerpt

PURPOSE: We recently showed that low microsatellite instability (MSI-L) is associated with a good response to platinum/5-fluorouracil (5-FU) neoadjuvant chemotherapy (CTx) in gastric cancer. The purpose of this study was to characterize the instability pattern and to investigate an association of MSI-L tumors with mutations in genes of DNA repair pathways and with total tumor mutation burden (TMB). METHODS: MSI...

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Identifiers

PMID: 37819581
DOI: 10.1007/s00432-023-05430-6
PMCID: PMC10725348

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