Article
Target gene mutation profile differs between gastrointestinal and endometrial tumors with mismatch repair deficiency.
Cancer research - 15 Mar 2002
Duval Alex, Reperant Maryline, Compoint Aurore, Seruca Raquel, Ranzani Guglielmina N, Iacopetta Barry, Hamelin Richard
Abstract excerpt
Mutation frequencies at 25 genes containing coding repeats were compared in colorectal, gastric, and endometrial mismatch repair-deficient (MSI-H) tumors. The overall number of mutations was significantly lower in endometrial than in gastrointestinal MSI-H cancers. Using a likelihood statistical method, target genes were divided in each tumor location into two groups likely to represent gene mutations that do or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.