Article
Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.
The Journal of pharmacology and experimental therapeutics - 1 Aug 2004
Jiang Weiwu, Welty Stephen E, Couroucli Xanthi I, Barrios Roberto, Kondraganti Sudha R, Muthiah Kathirvel, Yu Ling, Avery Stephen E, Moorthy Bhagavatula
Abstract excerpt
Administration of supplemental oxygen is frequently encountered in infants suffering from pulmonary insufficiency and in adults with acute respiratory distress syndrome. However, hyperoxia causes acute lung damage in experimental animals. In the present study, we investigated the roles of the Ah...
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