Article
Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines.
BMC neuroscience - 24 Mar 2009
Shiraishi-Yamaguchi Yoko, Sato Yumi, Sakai Rieko, Mizutani Akihiro, Knöpfel Thomas, Mori Nozomu, Mikoshiba Katsuhiko, Furuichi Teiichi
Abstract excerpt
BACKGROUND: Homer is a postsynaptic scaffold protein that links various synaptic signaling proteins, including the type I metabotropic glutamate receptor subunits 1alpha and 5, the inositol 1,4,5-trisphosphate receptor, Shank and Cdc42 small GTPase. Overexpression of Homer induces changes in dendritic spine morphology in cultured hippocampal neurons. However, the molecular basis underpinning Homer-mediated spine...
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