Gender-specific protective effect of the -463G>A polymorphism of myeloperoxidase gene against the risk of essential hypertension in Russians.

doi:10.1016/j.jash.2015.08.006

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Article

Gender-specific protective effect of the -463G>A polymorphism of myeloperoxidase gene against the risk of essential hypertension in Russians.

Journal of the American Society of Hypertension : JASH - 1 Nov 2015

Bushueva Olga, Solodilova Maria, Ivanov Vladimir, Polonikov Alexey

Abstract excerpt

The purpose of this study was to investigate whether a common polymorphism -463G>A (rs2333227) in the promoter of myeloperoxidase (MPO) gene, an oxidant enzyme producing hypohalogenic radicals, is associated with the risk of essential hypertension (EH) in Russian population. A total of 2044 unrelated subjects including 1256 EH patients and 788 normotensive controls were recruited for this study. Genotyping of the...

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PMID: 26431910
DOI: 10.1016/j.jash.2015.08.006

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