Article
Plasma myeloperoxidase level and peripheral arterial disease.
European journal of clinical investigation - 1 May 2012
Haslacher Helmuth, Perkmann Thomas, Gruenewald Julia, Exner Markus, Endler Georg, Scheichenberger Vanessa, Wagner Oswald, Schillinger Martin
Abstract excerpt
BACKGROUND: Myeloperoxidase (MPO) is involved in a multitude of inflammatory processes involving oxidative modification of soluble components and cellular surfaces. Thus, MPO plays a key role in promoting atherosclerosis via oxidative stress by modification of both high- and low-density lipoprotein and production of other bioactive molecules. A polymorphism (MPO 463G>A, rs2333227) results in different expression...
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