Role of Leu-beta 88 in the hydrophobic acceptor pocket for Val-beta 6 during hemoglobin S polymerization.

Article

Role of Leu-beta 88 in the hydrophobic acceptor pocket for Val-beta 6 during hemoglobin S polymerization.

The Journal of biological chemistry - 1 Jul 1994

Adachi K, Konitzer P, Paulraj C G, Surrey S

Abstract excerpt

X-ray crystallographic studies indicate that the hydrophobic acceptor pocket made by E and F helices involving Leu-beta 88 and Phe-beta 85 is critical for the formation of stable hydrophobic interactions with Val-beta 6 on an adjacent deoxy-hemoglobin (Hb) S tetramer. Ala and Phe substitutions at...

Topics

Biopolymers
Hemoglobin, Sickle
Hot Temperature
Humans
Leucine
Mutation
Oxygen
Recombinant Proteins
Valine

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