Article

Conserved phosphorylatable residues in motif G of positive-stranded virus RdRps regulate polymerase activity and suggest targets for drug design

2025-12-09

Abstract excerpt

RNA viruses rely on an RNA-dependent RNA polymerase (RdRp) to replicate their genome. RdRps share a conserved core replicase structure described as a right hand within which RNA replication occurs. RNA polymerases contain a series of conserved motifs (A-G) that are essential for catalysis. Motif G, located at the RNA entry channel, guides the incoming RNA into the catalytic centre and and holds it in place during...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 172e27f4-051b-50e0-a7f2-886eedd480f0
DOI: 10.64898/2025.12.08.692995

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Conserved phosphorylatable residues in motif G of positive-stranded virus RdRps regulate polymerase activity and suggest targets for drug designDOI 10.64898/2025.12.08.692995Read

Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virusSemantic proximity Read

Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of AntiviralsSemantic proximity Read

Manganese-dependent polioviruses caused by mutations within the viral polymerase.Semantic proximity Read

Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibitionSemantic proximity Read

Functional benefit of structural disorder for the replication of measles, Nipah and Hendra virusesSemantic proximity Read

Characterization of the Interaction Domains between the Phosphoprotein and the Nucleoprotein of Human Metapneumovirus.Semantic proximity Read

Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in ChinaSemantic proximity Read

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in <i>Betacoronavirus</i> replicationSemantic proximity Read

A template RNA entry channel in the fingers domain of the poliovirus polymerase.Semantic proximity Read

Specific Residues in the C-Terminal Domain of the Human Metapneumovirus Phosphoprotein Are Indispensable for Formation of Viral Replication Centers and Regulation of the Function of the Viral Polymerase ComplexSemantic proximity Read

Mechanism of SARS-CoV-2 Nucleocapsid Protein Phosphorylation-induced Functional SwitchSemantic proximity Read

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase InterfaceSemantic proximity Read