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Article

Mutational analysis of positively charged amino acid residues of Uukuniemi phlebovirus nucleocapsid protein.

Virus research - 1 Jul 2012

Katz Anna, Freiberg Alexander N, Backström Vera, Holm Liisa, Vaheri Antti, Flick Ramon, Plyusnin Alexander

Abstract excerpt

The aim of this study was to evaluate the contribution of positively charged amino acid residues for the Uukuniemi virus (UUKV) N protein functionality. Based on phlebovirus nucleocapsid (N) protein alignments and 3D-structure predictions of UUKV N protein, 14 positively charged residues were chosen as targets for the mutagenesis. The impact of mutations to the N protein functionality was analyzed using...

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PMID: 22808531
DOI: 10.1016/j.virusres.2012.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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