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Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition

7 Jul 2025

Abstract excerpt

The measles virus (MeV), a highly contagious non-segmented negative-sense RNA virus in the Paramyxoviridae family, causes millions of infections annually, with no approved antivirals available. The viral polymerase complex, comprising the large (L) protein and the tetrameric phosphoprotein (P), is a key antiviral target. We determined the cryo-electron microscopy structures of the MeV polymerase complex alone and...

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Identifiers

PMID: 40628260
DOI: 10.1016/j.cell.2025.06.017

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