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Article

Mutations of the <i>BRAF</i> gene in cholangiocarcinoma but not in hepatocellular carcinoma

11 Apr 2003

Abstract excerpt

BACKGROUND: The Raf/MEK/ERK (mitogen activated protein kinase-MAPK) signal transduction cascade is an important mediator of a number of cellular fates, including growth, proliferation, and survival. The BRAF gene, one of the human isoforms of RAF, is activated by oncogenic Ras, leading to cooperative effects in cells responding to growth factor signals. AIMS: The aim of this study was to elucidate a possible...

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Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Hepatocellular Carcinoma Treatment and Prognosis
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12692057
DOI: 10.1136/gut.52.5.706

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