BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy

Abstract excerpt

Poor data have been previously reported about the mutation rates in K-RAS, BRAF, and PIK3CA genes among patients with hepatocellular carcinoma (HCC). Here we further elucidated the role of these genes in pathogenesis of primary hepatic malignancies. Archival tumour tissue from 65 HCC patients originating from South Italy were screened for mutations in these candidate genes by direct sequencing. Overall, oncogenic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hepatocellular Carcinoma Treatment and Prognosis
• Share to Melanoma and MAPK Pathways
• Share to PI3K/AKT/mTOR signaling in cancer