Protein expression and genetic alterations of p53 and ras in intrahepatic cholangiocarcinoma

doi:10.1046/j.1365-2559.1999.00705.x

Article

Protein expression and genetic alterations of p53 and ras in intrahepatic cholangiocarcinoma

1 Sept 1999

Abstract excerpt

AIMS: The significance of molecular and genetic alterations of p53 and ras in the development and progression as well as the histological differentiation of intrahepatic cholangiocarcinoma (ICC) was evaluated. METHODS AND RESULTS: We examined immunohistochemically ras p21 protein and p53-related products (p53 protein, WAF-1 and mdm-2) in 43 cases of ICC. In addition, point mutations of ras and p53 were examined...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Protein expression and genetic alterations of <i>p53</i> and <i>ras</i> in intrahepatic cholangiocarcinoma

Abstract excerpt

Discuss the evidence