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Article

BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent.

Science signaling - 21 Apr 2015

Margalef Pol, Colomer Carlota, Villanueva Alberto, Montagut Clara, Iglesias Mar, Bellosillo Beatriz, Salazar Ramón, Martínez-Iniesta María, Bigas Anna, Espinosa Lluís

Abstract excerpt

KRAS mutations contribute to cell proliferation and survival in numerous cancers, including colorectal cancers (CRC). One pathway through which mutant KRAS acts is an inflammatory pathway that involves the kinase IKK and activates the transcription factor NF-κB. BRAF, a kinase that is downstream of KRAS, is mutated in a subset of CRC and is predictive of poor prognosis and therapeutic resistance. We found that,...

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Source

Identifiers

PMID: 25900832
DOI: 10.1126/scisignal.2005886

Genes

BRAF
KRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent.PMID 25900832Read ↗

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