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Article

Requirement of gp130 signaling for the AGM hematopoiesis.

Experimental hematology - 1 Apr 2003

Takizawa Makiko, Nobuhisa Ikuo, Igarashi Katsuhide, Ueno Masaya, Nakashima Kinichi, Kitamura Toshio, Taga Tetsuya

Abstract excerpt

OBJECTIVE: Definitive hematopoiesis starts in the aorta-gonad-mesonephros (AGM) region during mouse development and remarkably expands in the liver at a later stage of ontogeny. gp130 is a signal transducing receptor component shared by all the IL-6 family cytokines, whose gene ablation in mouse results in the significant reduction in the fetal liver hematopoiesis. The present study aims to evaluate the role of...

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Source

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PMID: 12691915
DOI: 10.1016/s0301-472x(03)00025-0

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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