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Article

Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas.

International journal of epidemiology - 1 Feb 2003

Marugame Tomomi, Tsuji Emiko, Kiyohara Chikako, Eguchi Hiroyuki, Oda Takashi, Shinchi Koichi, Kono Suminori

Abstract excerpt

BACKGROUND: Folate intake may be related to decreased risk of colorectal cancer and adenomas. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate metabolism. We examined the relation between plasma folate status and colorectal adenomas with reference to effect modification by the genetic polymorphism (C677T) of MTHFR. METHODS: Study subjects were middle-aged Japanese men: 177 cases of...

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Source

Identifiers

PMID: 12690011
DOI: 10.1093/ije/dyg004

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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