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Article

Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas.

International journal of epidemiology - 1 Feb 2003

Marugame Tomomi, Tsuji Emiko, Kiyohara Chikako, Eguchi Hiroyuki, Oda Takashi, Shinchi Koichi, Kono Suminori

Abstract excerpt

BACKGROUND: Folate intake may be related to decreased risk of colorectal cancer and adenomas. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate metabolism. We examined the relation between plasma folate status and colorectal adenomas with reference to effect modification by the genetic polymorphism (C677T) of MTHFR. METHODS: Study subjects were middle-aged Japanese men: 177 cases of...

Topics

Adenoma
Case-Control Studies
Colorectal Neoplasms
Folic Acid
Genotype
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Odds Ratio
Oxidoreductases Acting on CH-NH Group Donors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Risk

Source

Identifiers

PMID: 12690011
DOI: 10.1093/ije/dyg004

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12690011-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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