Article
Methylenetetrahydrofolate reductase polymorphism and risk of colorectal adenomas.
Cancer letters - 14 Apr 2000
Marugame T, Tsuji E, Inoue H, Shinomiya S, Kiyohara C, Onuma K, Hamada H, Koga H, Handa K, Hayabuchi H, Kono S
Abstract excerpt
A homozygous mutation at bp 677 in the gene for the methylenetetrahydrofolate reductase (MTHFR) was previously shown to be associated with a decreased risk of colorectal cancer. We examined the relation between the MTHFR genetic polymorphism and risk of colorectal adenoma in Japanese men using 205 cases of colorectal adenomas and 220 controls of normal total colonoscopy. The homozygous mutation was not measurably...
Topics
- Adenoma
- Alcohol Drinking
- Colorectal Neoplasms
- Genetic Predisposition to Disease
- Homozygote
- Humans
- Japan
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation