Article
Genetic and environmental determinants of plasma nitrogen oxides and risk of ischemic heart disease.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2001
Jeerooburkhan N, Jones L C, Bujac S, Cooper J A, Miller G J, Vallance P, Humphries S E, Hingorani A D
Abstract excerpt
Endothelial dysfunction, caused in part by reduced NO bioavailability, is a feature of hypercholesterolemia, hypertension, smoking, and atherosclerosis. We examined whether cholesterol, blood pressure, smoking status, and polymorphisms in the endothelial NO synthase gene (NOS 3) influence NO production (as assessed by the plasma levels of nitrogen oxides, NO(x)) in middle-aged men. We also determined whether...
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