Article
Nitric oxide synthase gene polymorphisms and diabetic nephropathy.
Diabetologia - 1 Mar 2003
Rippin J D, Patel A, Belyaev N D, Gill G V, Barnett A H, Bain S C
Abstract excerpt
AIMS/HYPOTHESIS: Susceptibility to diabetic nephropathy in subjects with Type 1 diabetes is mainly genetically determined. Excess cardiovascular risk associated with diabetes is overwhelmingly concentrated in patients with nephropathy. Endothelial dysfunction is a feature of cardiovascular disease, hypertension, dyslipidaemia and smoking, all of which are associated with diabetic nephropathy. Nitric oxide...
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