Article
Endothelial nitric oxide synthase gene polymorphisms and risk of diabetic nephropathy: a systematic review and meta-analysis.
BMC medical genetics - 16 Jan 2014
Dellamea Bruno Schmidt, Pinto Lana Catani Ferreira, Leitão Cristiane Bauermann, Santos Katia Gonçalves, Canani Luis Henrique Santos
Abstract excerpt
BACKGROUND: Nitric oxide (NO) has numerous functions in the kidney, including control of renal and glomerular hemodynamics, by interfering at multiple pathological and physiologically critical steps of nephron function. Endothelial NOS (eNOS) gene has been considered a potential candidate gene to diabetic nephropathy (DN) susceptibility. Endothelial nitric oxide synthase gene (eNOS-3) polymorphisms have been...
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