Article
Endothelial nitric oxide synthase gene intron 4 polymorphism in type 2 diabetes mellitus.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Jan 2003
Ksiazek Piotr, Wojewoda Pawel, Muc Kamil, Buraczynska Monika
Abstract excerpt
INTRODUCTION: Endothelial nitric oxide synthase (ecNOS) is a key regulator of vascular nitric oxide production. Polymorphism in intron 4 of the ecNOS gene is implicated in cardiovascular and renal diseases. We investigated a potential involvement of this polymorphism in the development of type 2 diabetes mellitus and its renal complications. METHODS: This preliminary study involved 410 individuals with type 2...
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