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Article

Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7.

Journal of molecular biology - 18 Apr 2003

Beltz Hervé, Azoulay Joel, Bernacchi Serena, Clamme Jean-Pierre, Ficheux Damien, Roques Bernard, Darlix Jean-Luc, Mély Yves

Abstract excerpt

Reverse transcription of HIV-1 genomic RNA to double-stranded DNA by reverse transcriptase (RT) is a critical step in HIV-1 replication. This process relies on two viral proteins, the RT enzyme and nucleocapsid protein NCp7 that has well documented nucleic acid chaperone properties. At the beginning of the linear DNA synthesis, the newly made minus-strand strong-stop DNA ((-)ssDNA) is transferred to the 3'end of...

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Identifiers

PMID: 12684000
DOI: 10.1016/s0022-2836(03)00244-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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