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Article

Effect of TAR hairpin stabilization on HIV-1 reverse transcription.

Journal of virology - 19 May 2026

Da Silva Amaral Sandra, Richetta Clémence, Oualid Lola, Tu Nhat Quang, René Brigitte, Mauffret Olivier, Delelis Olivier, Fossé Philippe

Abstract excerpt

Reverse transcription of the human immunodeficiency virus type 1 (HIV-1) genome requires the first strand transfer that relies on a base-pairing interaction between the 3' R sequence of the genomic RNA (gRNA) and the r sequence of the strong-stop DNA (ssDNA). The annealing reaction between the cTAR hairpin of ssDNA and the TAR hairpin of gRNA plays an essential role in r-3' R pairing. Studies suggest that HIV-1...

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Share to DNA, Single-Stranded
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Long Terminal Repeat

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Share to Nucleic Acid Conformation

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Source

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Identifiers

PMID: 42053302
DOI: 10.1128/jvi.01840-25
PMCID: PMC13185573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Effect of TAR hairpin stabilization on HIV-1 reverse transcription.PMID 42053302Read ↗

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