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Article

Structural and dynamic characterization of the upper part of the HIV-1 cTAR DNA hairpin.

Nucleic acids research - 1 Jul 2009

Zargarian Loussiné, Kanevsky Igor, Bazzi Ali, Boynard Jonathan, Chaminade Françoise, Fossé Philippe, Mauffret Olivier

Abstract excerpt

First strand transfer is essential for HIV-1 reverse transcription. During this step, the TAR RNA hairpin anneals to the cTAR DNA hairpin; this annealing reaction is promoted by the nucleocapsid protein and involves an initial loop-loop interaction between the apical loops of TAR and cTAR. Using NMR and probing methods, we investigated the structural and dynamic properties of the top half of the cTAR DNA...

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Identifiers

PMID: 19417069
DOI: 10.1093/nar/gkp297
PMCID: PMC2709575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural and dynamic characterization of the upper part of the HIV-1 cTAR DNA hairpin.PMID 19417069Read ↗

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