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Article

An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis

1 Oct 2006

Abstract excerpt

In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the human chromosome 10q26.3 was found to be deleted or methylated in 73% of the examined cases of brain tumors. EBF3 is expressed in normal brain but is silenced in brain tumors. Therefore, it is suggested that EBF3 is a tumor suppressor. However, it remains unknown whether inactivation of EBF3 locus also occurs in other types of...

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PMID: 17018599
DOI: 10.1158/0008-5472.can-06-1713

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