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Article

Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutation

1 Jan 2013

Abstract excerpt

Long QT syndrome (LQTS) is a congenital abnormality of cardiac repolarization that manifests as a prolonged QT interval on 12-lead electrocardiograms (ECGs). The syndrome may lead to syncope and sudden death from ventricular tachyarrhythmias known as torsades de pointes. An increased persistent Na(+) current is known to cause a Ca(2+) overload in case of ischemia for example. Such increased Na(+) persistent...

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Identifiers

PMID: 24098284
DOI: 10.3389/fphar.2013.00126

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