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Article

Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice.

American journal of respiratory cell and molecular biology - 1 Sept 2003

Nagao Koichi, Tanaka Hiroyuki, Komai Masato, Masuda Taisei, Narumiya Shuh, Nagai Hiroichi

Abstract excerpt

Recently, we demonstrated that prostaglandin (PG)I2 has a regulatory role in allergic responses through the receptor, IP; however, the role of PGI2 in airway remodeling associated with chronic airway inflammation has not been elucidated. In the present study, we examined the role of PGI2 in allergen-induced airway remodeling using IP gene-deficient mice. Mice were sensitized to ovalbumin (OVA) with alum, and...

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Identifiers

PMID: 12676807
DOI: 10.1165/rcmb.2003-0035OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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