Article
The Rho family of small GTPases is involved in epithelial cystogenesis and tubulogenesis.
Kidney international - 1 May 2003
Rogers Katherine K, Jou Tzuu-Shuh, Guo Wei, Lipschutz Joshua H
Abstract excerpt
BACKGROUND: Epithelial cyst and tubule formation represent critical processes for the development of many mammalian organs and involve transient, highly choreographed changes in cell polarity. The Rho family of small GTPases, whose prototypes are RhoA, Rac1, and Cdc42, regulate many biologic processes, including cell polarization and morphogenesis. The exocyst is a conserved eight-subunit protein complex involved...
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