Article
Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002
Hampe Jochen, Frenzel Henning, Mirza Muddassar M, Croucher Peter J P, Cuthbert Andrew, Mascheretti Silvia, Huse Klaus, Platzer Matthias, Bridger Stephen, Meyer Birgit, Nürnberg Peter, Stokkers Pieter, Krawczak Michael, Mathew Christopher G, Curran Mark, Schreiber Stefan
Abstract excerpt
Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by analysis of multiple populations. NOD2, located on proximal 16q, was recently identified as an IBD gene. As the linkage regions on chromosome 16 are large, we have investigated the possibility that NOD2 is not the only...
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