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Article

A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.

The Journal of biological chemistry - 13 Jun 2003

Lynch Danielle K, Winata Stephanie C, Lyons Ruth J, Hughes William E, Lehrbach Gillian M, Wasinger Valerie, Corthals Garry, Cordwell Stuart, Daly Roger J

Abstract excerpt

Growth factor regulation of the cortical actin cytoskeleton is fundamental to a wide variety of cellular processes. The cortical actin-associated protein, cortactin, regulates the formation of dynamic actin networks via the actin-related protein (Arp)2/3 complex and hence is a key mediator of such responses. In order to reveal novel roles for this versatile protein, we used a proteomics-based approach to isolate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fluorescent Antibody Technique, Indirect

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Source

Identifiers

PMID: 12672817
DOI: 10.1074/jbc.M211407200

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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