Article
CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies.
Molecular biology of the cell - 1 Sept 2012
Schroeder Barbara, Srivatsan Subhashini, Shaw Andrey, Billadeau Daniel, McNiven Mark A
Abstract excerpt
Ubiquitination of the epidermal growth factor receptor (EGFR) by cbl and its cognate adaptor cbl-interacting protein of 85 kDa (CIN85) is known to play an essential role in directing this receptor to the lysosome for degradation. The mechanisms by which this ubiquitin modification is regulated are not fully defined, nor is it clear where this process occurs. In this study we show that EGFR activation leads to a...
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