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Article

CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.

The American journal of pathology - 1 Dec 2001

Shih N Y, Li J, Cotran R, Mundel P, Miner J H, Shaw A S

Abstract excerpt

CD2AP, an adapter protein containing multiple SH3 domains, plays a critical role in kidney function. Mice lacking CD2AP die soon after birth because of kidney failure. In the kidney, CD2AP is expressed in glomerular podocytes, which suggests that it may play a role in a specialized adhesion complex known as the slit diaphragm. One of the major components of the slit diaphragm is nephrin, a podocyte-specific...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11733379
DOI: 10.1016/S0002-9440(10)63080-5
PMCID: PMC1850607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.PMID 11733379Read ↗

CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.Semantic proximity Read ↗

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CD2-associated protein and glomerular disease.Semantic proximity Read ↗

CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency.Semantic proximity Read ↗

Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot processSemantic proximity Read ↗

CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS).Semantic proximity Read ↗

CD2AP and p130Cas localize to different F-actin structures in podocytesSemantic proximity Read ↗

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survivalSemantic proximity Read ↗

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility.Semantic proximity Read ↗

Role of podocyte slit diaphragm as a filtration barrier (Review Article)Semantic proximity Read ↗

The tricellular junctional protein Ildr2 helps maintain glomerular podocyte architectureSemantic proximity Read ↗

CIN85/RukL Is a Novel Binding Partner of Nephrin and Podocin and Mediates Slit Diaphragm Turnover in PodocytesSemantic proximity Read ↗

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