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Article

DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines

14 Nov 2002

Abstract excerpt

The CDM (ced-5 of Caenorhabditis elegans, DOCK180 [downstream of Crk with molecular weight of 180 kDa] of humans, and myoblast city of Drosophila melanogaster) family of proteins has been shown to play a pivotal role in the integrin-mediated signaling pathway under the regulation of an adaptor molecule c-CT10-related kinase II (c-Crk-II) in adherent cells. Recently, hematopoietic cell-specific CDM protein DOCK2...

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Identifiers

PMID: 12393632
DOI: 10.1182/blood-2001-11-0032

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