Article
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.
Blood - 1 Oct 2007
Brender Christine, Tannahill Gillian M, Jenkins Brendan J, Fletcher Joel, Columbus Ruth, Saris Christiaan J M, Ernst Matthias, Nicola Nicos A, Hilton Douglas J, Alexander Warren S, Starr Robyn
Abstract excerpt
Suppressor of cytokine signaling (SOCS) proteins regulate the intensity and duration of cytokine responses. SOCS3 is expressed in peripheral T cells, and recent reports have suggested that overexpression of SOCS3 modulates antigen- and/or costimulation-induced T-cell activation. To study the role of SOCS3 in the regulation of T-cell activation, we used a conditional gene-targeting strategy to generate mice that...
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